• br Potency efficacy and biocharacter Dose

  2020-08-03

  

  Potency, efficacy and biocharacter Dose response analysis (Fig. 2) can be performed on Kif15-IN-1 in culture, in tissue, in animals or even in patients. Many different responses can be measured, including mRNA levels, reporter gene activity, gene product (e.g. enzyme) activity or even physiologi

• br Materials and Methods br Results br Discussion The abilit

  2020-08-03

  

  Materials and Methods Results Discussion The ability of pathogens to modulate the host fibrinolytic system is a crucial characteristic for tissue invasion. Plasminogen is an abundant protein of the host fibrinolytic system which upon activation into plasmin dissolves fibrin clots [12]. Eith

• LEE011 In addition to the C and catalytic domains DGKs

  2020-08-03

  

  In addition to the C1 and catalytic domains, DGKs have other regulatory domains that form the basis for dividing them into five subtypes. Type I DGKs [29], [30], [31] have calcium-binding EF hand motifs and are more active in the presence of calcium [32]. Type II DGKs have pleckstrin homology (PH) d

• br Results and discussion As previously

  2020-08-03

  

  Results and discussion As previously reported, the bicyclic core of 1 arose from analyses of alternative cores that retained what were assumed to be the key pharmacophore elements of 2 and the spatial orientation of these in three-dimensional space. Incorporation of the fused, seven-membered lact

• Molidustat In addition there are also a

  2020-08-01

  

  In addition, there are also a few researches about applying dedication processes into COTS SW. Kim et al. (2000) proposed a COTS SW dedication process based on NUREG/CR-6421 and used methods of TR-106439 to apply SQA identification. However, it does not mention about indirect SW and uses the method

• br Introduction Zearalenone ZEA chemically described as

  2020-07-31

  

  Introduction Zearalenone (ZEA), chemically described as 6-(10-hydroxy-6-oxo-trans-1-undecenyl)-β-resocyclic Medroxyprogesterone acetate lactone, is one of the well-known mycotoxins produced by Fusarium species, whose contamination is present world-wide (W. Zheng et al., 2018). Human and animal e

• It is generally accepted that

  2020-07-31

  

  It is generally accepted that the differentiation of human induced pluripotent stem cells (hiPSCs) to functional β cells offers exciting opportunities to treat diabetes. Thus, several groups have now reported protocols for the generation of glucose-responsive functional β cells from hiPSCs (Rezania

• The human neutrophil elastase HNE is a proteolytic enzyme

  2020-07-31

  

  The human neutrophil elastase (HNE) is a proteolytic enzyme that plays a central role in several inflammatory diseases. An imbalance between HNE and its endogenous inhibitors lead to severe tissue injuries triggering various disease as for instance rheumatoid arthritis, chronic obstructive pulmonary

• Lipotoxicity is the result of an imbalance between lipid upt

  2020-07-31

  

  Lipotoxicity is the result of an imbalance between lipid uptake and utilization. Saturated fatty acids (FAs) cause considerably more aggravating effects than unsaturated FAs. One possible reason for this is that the saturated FA palmitate leads to greater ceramide synthesis [13], triggers reactive o

• An important question is to what extent any differences

  2020-07-31

  

  An important question is to what extent any differences in radioligand characteristics may have contributed to discrepancies between studies. Two studies on schizophrenia addressed this question directly by using [11C]SCH 23390 and [11C]NCC 112 in the same individuals, not finding any differences be

• We finally examined whether N BMAA is cytotoxic to

  2020-07-31

  

  We finally examined whether N-BMAA is cytotoxic to SH-SY5Y cells. SH-SY5Y is an immortalised neuroblastoma cell line with many of the characteristics of neuronal cells. It is used commonly for investigations of BMAA induced neuronal toxicity and in other studies relating to AD, ALS, and ALS/PDC (Lop

• The proof of concept chemogenomic profiling experiments

  2020-07-31

  

  The proof of concept chemogenomic profiling experiments in P. falciparum (Fig. 3A) showed that the primary drug target can be revealed as a significant EC50 ratio. All antifolates were identified as DHFR-TS targeting drugs, despite the wide variation in antimalarial potency from the extremely potent

• br Acknowledgements This work was supported by

  2020-07-30

  

  Acknowledgements This work was supported by the National Natural Science Foundation of China (31572039), the National Program on Key Basic Research Projects (973 Program, 2013CB127600) and China Postdoctoral Science Foundation (2016M601946). Introduction Parkinson\'s disease (PD) is a neurolo

• The IV chains of mature GBM are

  2020-07-30

  

  The α3/α4/α5(IV)-chains of mature GBM are built exclusively by podocytes (not by endothelial cells) (Abrahamson et al., 2009), placing the podocytes into the focus of GBM-diseases such as Alport syndrome. Alport syndrome (AS) is caused by mutations in the COL4A3, 4 or 5 genes coding for the α3/α4/α5

• br Materials and methods br Results

  2020-07-30

  

  Materials and methods Results Discussion We found that CysLT2 receptors were constitutively expressed in bronchial smooth muscle cells, and that CysLT2 receptor-expressing leukocytes, mainly consisting of macrophage/dendritic cells and eosinophils, infiltrated into the lung after multiple a

16321 records 845/1089 page Previous Next First page 上5页 841842843844845 下5页 Last page