• In a previous study M ykkynen et al

  2022-10-12

  

  In a previous study (Möykkynen et al., 2003), we reported that ethanol lengthens the time needed for the AMPA receptors to recovery from desensitization in isolated hippocampal neurons. Here, we did not observe any effect of ethanol on recovery from desensitization in recombinant homomeric GluR-D re

• br Acknowledgments br Introduction Postmenopausal osteoporos

  2022-10-12

  

  Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by Gefitinib deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women, and approximately 30% of p

• br Some Gardos channel perplexities

  2022-10-11

  

  Some Gardos channel perplexities While much is known about the Gardos channel (inside Ca2+-activated K+ channel) and it's characteristics in human red blood R788 (e.g. [18,19]), there are a number of intriguing and unexplained phenomena that are in much need of study. One is that activation of t

• SCPNs and CPNs exhibit similar strength

  2022-10-11

  

  SCPNs and CPNs exhibit similar strength of electrical coupling (Maruoka et al., 2017) and had similar membrane properties (Experimental Procedures), and showed no significant difference in amplification and synchronization (Figs. 2E and 3C). However, a subset of CPNs exhibit very strong electrical c

• Since our new compound Fex

  2022-10-11

  

  Since our new compound Fex-3 could be a new FXR ligand, we try to demonstrate that Fex-3 was an intestinal-restricted FXR agonist which only activated FXR in the intestine not in the liver or other organs. Initially, we investigated this in Caco-2 Luciferase Reporter Assay Kit with transwell experi

• RGDfK On the other hand histone

  2022-10-11

  

  On the other hand, histone deacetylase inhibitors can accelerate inflammation resolution by promoting the externalization of AnxA1, a main ALX/FPR2 agonist, with concomitant inhibition of cytokine gene expression in mouse macrophages [30]. Thus, our present results provide an additional mechanism, i

• Recently we indicated that cell motility

  2022-10-11

  

  Recently, we indicated that cell motility was regulated by the different induction of GPR120 and GPR40 in liver epithelial WB-F344 Fructose australia treated with chemical agents. The cell motility of WB-F344 cells was stimulated by phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) which is

• Ning et al showed that LPC appeared to increase insulin

  2022-10-11

  

  Ning et al. showed that LPC 18:1 appeared to increase insulin release through both GPR119-dependent and -independent mechanisms (Ning et al., 2008). In our study, we have shown that not only GPR119 but also GPR40 and GPR55 participate in LPC-stimulated insulin secretion (Fig. 4, Fig. 5) and target p

• Gastrodin Through experimental models and clinical experimen

  2022-10-11

  

  Through experimental models and clinical experiments, those four drugs above can shown efficacy-enhancing and toxicity-reducing effects after compatibility. Our preclinical studies showed that XFC has a definite effect on relieving joint symptoms in RA patients. XFC can improve joint pain, swelling,

• Most studies to date have focused on

  2022-10-11

  

  Most studies to date have focused on the physiological functions of FPS in plants. As mentioned above, numerous factors affect FPS expression and FPS function. However, FPS enzymatic assays require radiolabeled substrate and thus detailed enzymatic characterizations of FPS, including substrate speci

• EZH mutations or amplifications have been

  2022-10-11

  

  EZH2 mutations or amplifications have been found in a broad spectrum of human cancers including B cell lymphoma, ovarian cancer, breast cancer, melanoma, bladder cancer, gastric cancer, and other cancers (Kim and Roberts, 2016). Given the evidence of EZH2 as a cancer driver, numerous efforts have be

• While considering the molecular pathogenesis of an

  2022-10-10

  

  While considering the molecular pathogenesis of an MPNST, the Ras/Raf/MEK/ERK, mTOR/AKT, p53, and PTEN pathways associated with tumor growth have been described (McCubrey et al., 2012). The involvement of receptor tyrosine kinases such as EGFR and TAM receptor families, and its associated molecular

• br Acknowledgement The work was

  2022-10-10

  

  6. Acknowledgement The work was supported by the NSFC through Grant Nos. 11535016 and 11475232. It was also supported by CAS. The authors thank their collaborators for beneficial discussions and enthusiastic supports in the simulations and calculations. Introduction Hypoxia-inducible factors

• br Experimental section The parts of chemicals

  2022-10-10

  

  Experimental section The parts of chemicals and regents, preparation of solutions, pre-treatment of the bare Au electrode, cell culture, cytotoxicity in vitro, cell imaging, characterizations, and electrochemical measurements are supplied in the S1 (See the Supplementary Information). The prepara

• GCIPs are highly conserved Ca binding proteins first discove

  2022-10-10

  

  GCIPs are highly conserved Ca2+-binding proteins first discovered in the frog [42] and later in teleost [9]. With regard to gene structure, sequence conservation, and function, GCIPs are evolutionarily related to the GCAPs. The GCIP genes have acquired an additional intron in the N-terminal region w

15894 records 368/1060 page Previous Next First page 上5页 366367368369370 下5页 Last page