• Our results add to previously published data on the contribu

  2024-07-08

  

  Our results add to previously published data on the contribution of ALDH3A1 to the optical properties of the cornea. Specifically, the study by Nees et al. (2002) was among the first to examine whether ALDH3A1 serves as a structural component in the cornea and similarly to lens crystallins. Their ex

• GSK256066 australia The observation that vortioxetine blocks

  2024-07-08

  

  The observation that vortioxetine blocks 5-HT-induced currents in 5-HT3 receptor-expressing oocytes suggests that vortioxetine acts to functionally antagonize these receptors, and is in line with previously published data (Bang-Andersen et al., 2011). For example, Mørk et al. (2012) demonstrated tha

• br Results br Discussion Our finding that AXL

  2024-07-06

  

  Results Discussion Our finding that AXL overexpression is significantly associated with poor survival in patients with high-grade serous OC is consistent with previous reports indicating that AXL regulates tumor growth in some cancers, as well as reports showing that AXL activity is involved i

• Another contributor for the G M arrest

  2024-07-06

  

  Another contributor for the G2/M arrest in A549 and H1299 cells might be p21WAF1/CIP1 which was up-regulated upon ovatodiolide treatment. p21WAF1/CIP1 is a common CDKs inhibitor which blocks hexokinase inhibition G2/M phase progression in various types of cancer cells (Kim et al., 2015, Liberio et

• br Materials and Methods br Results br Discussion

  2024-07-06

  

  Materials and Methods Results Discussion XHP is a traditional Chinese anti-cancer medicine that is widely used for the treatment and adjuvant treatment of breast cancer. XHP has been shown to induce apoptosis in various breast cancer LED209 in vitro, including Hs578T, MCF-7, and MDA-MB231

• ZSTK474 What are the in situ

  2024-07-06

  

  What are the in-situ effects of multi-site CaM associations with AT1R? Kai et al. showed that synthetic peptides corresponding to residues 125–137 (rat sequence) in SMD2, 217–227 in the N-terminal side of SMD3, and 304–316 in SMD4JM inhibit to various degrees AngII-induced GTPase activity of isolate

• Glucose permeability studies demonstrated a high glucose

  2024-07-05

  

  Glucose permeability studies demonstrated a high glucose flux through the SF films used in the present work. Recent diffusion studies, including small molecular drugs and oxygen permeation through SF membranes [32], further support the quality of SF and its possible application as a material for bio

• Although ACE genetic variance does not influence the level

  2024-07-05

  

  Although ACE genetic variance does not influence the level of bradykinin significantly, the bradykinin level tends to be affected by ACE inhibitor therapy used by patients. ACE inhibitor reduces the ACE activity that may lead to the accumulation of serum bradykinin. The level of bradykinin tends to

• Aromatization of the pyrrole ring

  2024-07-05

  

  Aromatization of the pyrrole ring after anion capturing, using acceptor atoms with electron deficiency (B & Be), and substitution of strong electron withdrawing groups such as CN were three strategies used to design a new class of anion receptors. Comparison of the anion affinities of these anion re

• Recent progress has been made

  2024-07-05

  

  Recent progress has been made in translating animal findings on memory performance and amnestic effects – that are largely determined by tonically active receptors in which α5 contributes to the benzodiazepine binding site. Based on the observation that deletion of this subunit led to improved spati

• As an internal control this study validated

  2024-07-04

  

  As an internal control, this study validated many of the known associations between GATA3 and predictive markers. GATA3 was shown to be associated with ER and PR, which are both well-known correlations. GATA3 was also negatively correlated with nuclear grade, which is consistent with our knowledge o

• br Author Contributions br Acknowledgments br Introduction

  2024-07-04

  

  Author Contributions Acknowledgments Introduction Cerebral ischemia-reperfusion (I/R) injury is a pathological phenomenon that occurs after restoration of blood supply to 4-P-PDOT tissues subsequent to ischemia or hypoxia (Carden and Granger, 2000). It typically occurs after therapeutic th

• br The lipoxygenase pathway in

  2024-07-04

  

  The 12/15-lipoxygenase pathway in vascular physiology and pathology The mammalian 12- and 15-LOXs have high substrate specificity oxidizing predominantly ω−6 (arachidonic and linoleic acids) but also the ω−3 (docosahexanoic) substance p [86], [87], [88]. Different LOXs oxidize fatty acids both in

• Mechanistically NAergic signaling in the VTA modulates neuro

  2024-07-04

  

  Mechanistically, NAergic signaling in the VTA modulates neuronal activity presumably via α1-AR. The majority of α1-ARs are found in the VTA are located presynaptically on unmyelinated L-365,260 synthesis and axon terminals of glutamatergic and GABAergic neurons. However, α1-ARs are also found on neu

• Proteinase K PAN induced nephrosis was accompanied

  2024-07-04

  

  PAN-induced nephrosis was accompanied by loss of body weight, decrease of food intake, increase in urine volume and increases in triglycerides and cholesterol levels, which have been reported previously (Natori et al., 1996). Except for urine volume, each one of these measures was improved by A-3069

16254 records 121/1084 page Previous Next First page 上5页 121122123124125 下5页 Last page