• An incisional biopsy was undertaken

  2019-06-01

  

  An incisional biopsy was undertaken. Peri-operative examination of the lesion revealed an expansile tumor mass brownish in color with focal whitish areas (Fig. 3). The lesion could be delineated from the surrounding cortical bone, and surrounding soft tissues. Histopathologically the biopsy material

• In addition to CAF in the primary tumour microenvironment it

  2019-06-01

  

  In addition to CAF in the primary tumour microenvironment, it is tempting to speculate that fibroblasts within the bone itself may play a role in the establishment of metastatic deposits. Fibroblasts form a major component of the bone marrow stroma and regulate haematopoiesis by secreting a range of

• Leptin synthesized in adipocytes is a regulator of fat

  2019-06-01

  

  Leptin, synthesized in adipocytes, is a regulator of fat metabolism and reproduction [7]. The levels of leptin correlate with body fat mass and show a wide variation in individuals. In the bone marrow microenvironment, the leptin secreting adipocytes occupy a significant part [8]. Leptin stimulates

• ICG-001 An imperative need now exists for

  2019-06-01

  

  An imperative need now exists for new thinking, increased resources, and better training of health-care staff working with these new populations. At a time when there is a danger of religiopolitical extremism in the wake of perceived (and sometimes real) antipathy to newcomers, the health sector has

• In order to treat metastatic

  2019-05-31

  

  In order to treat metastatic bone disease effectively all steps involved in the metastatic cascade need to be taken into account as for example the interactions between primary and secondary sites, tumour cell–bone cell cross talk and osteomimicri [8]. Therefore, concomitant targeting of both the tu

• br Bile acids as therapeutic agents br

  2019-05-31

  

  Bile acids as therapeutic agents Conclusion Bile acids are important physiological agents for nutrient igf ir and integrators of glucose, lipid, and energy metabolism control. Bile acid synthesis is tightly regulated to maintain metabolic homeostasis and prevent accumulation of highly toxic b

• Repurposing use of approved drugs for new indications

  2019-05-31

  

  Repurposing (use of approved drugs for new indications) or repositioning (use of drugs whose development was not continued for new indications) of existing drugs has been put forward as a method to overcome some of these issues. Indeed, drug repositioning and repurposing could lead to higher rates o

• br Unacceptably high rates of adverse outcomes persist

  2019-05-31

  

  Unacceptably high rates of adverse outcomes persist for childbearing women and infants, including maternal and newborn mortality, stillbirth, and short-term and long-term morbidity. In light of the challenges to achieve the UN Sustainable Development Goals, it is timely to reconsider priorities fo

• In Helen Nabwera and colleagues describe how

  2019-05-31

  

  In Helen Nabwera and colleagues describe how child growth in a rural African setting has changed during four decades of public health interventions. The investigators analysed data from an unparalleled resource: longitudinal growth monitoring across three Gambian villages spanning 36 years. The long

• br Case A year old

  2019-05-31

  

  Case A 45-year-old man was referred for the management of sudden-onset tachycardia. He had experienced 3 episodes of palpitation attacks, lasting for a couple of hours each, during the last 6 months. A regular, wide QRS complex tachycardia (WCT) at 150beats/min with a prominent retrograde P wave

• br Patients and methods br Discussion In

  2019-05-31

  

  Patients and methods Discussion In this methylphenidate hcl secondary endpoint analysis of the OPTION trial, we have shown that the addition of goserelin to neo(adjuvant) chemotherapy temporarily increased bone turnover during treatment and that this reverses over the next 6–12 months after co

• MK-2206 Data for each assessment point are expressed as the

  2019-05-31

  

  Data for each assessment point are expressed as the mean value plus standard deviation. One tailed paired t-tests were performed to analyze the effects of ibandronate treatment. Significance level was set at p Results The study included 33 patients with a variety of different primary tumors (Table

• El texto de Paz nos permite contemplar el estado como

  2019-05-31

  

  El texto de Paz nos permite contemplar el estado como una experiencia poética y una experiencia vital. Esto se debe en gran parte al énfasis que se pone en el cuerpo dihydrofolate reductase inhibitor lo largo de , y más propiamente en el cuerpo que avanza en el sendero de Galta. La caminata física

• Tuberculosis case finding and diagnostics

  2019-05-30

  

  Tuberculosis case-finding and diagnostics are far from perfect. The worldwide case detection rate of tuberculosis has stagnated at around 60%, not reaching the target of 70% originally set for 2000 but postponed to 2005, and then judged to be unreachable. In sub-Saharan Africa, case detection rates

• br TIEMPO DE CAMBIOS LA REINVENCI N IDENTITARIA DE DOS

  2019-05-30

  

  TIEMPO DE CAMBIOS: LA REINVENCIÓN IDENTITARIA DE DOS FELIGRESÍAS INDÍGENAS Hemos tenido ocasión de exponer que, en la capital mexicana, el tlaxilacalli de Acatla se habría favorecido notablemente del proceso de secularización de la parcialidad de San Pablo, que el arzobispo Montúfar condujo make

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